P-043 Increased paternal age adversely affects live birth rates in oocyte recipient cycles

Abstract Study question To investigate the influence of paternal age on live birth rates in oocyte recipient cycles Summary answer Increased appears to have a negative impact when adjusted for sperm quality. What is known already While effect maternal ART outcomes well established, unclear. Even systematic reviews assessing yielded conflicting results. Morris et al., 2020 could not demonstrate changes miscarriage or with increased age, Murugesu 2022 showed an adverse miscarriages but did comment rates. The challenges are heterogeneity studies and possible laboratory clinical practices. design, size, duration This retrospective cohort study was conducted at single centre. A total 449 IVF/ICSI performed between January 2015 June were examined. Total 328 resulting either fresh frozen-thawed embryo transfers meeting inclusion criteria analysed. donor ≤35 years, endometrial thickness ≥ 6 mm normal cavity aqua scan. We excluded PGT-A. Participants/materials, setting, methods couples who used oocytes because diminished ovarian reserve, premature insufficiency, recurrent implantation failure autologous hereditary disease participated. Paternal ages grouped according previous literature allow comparability. primary outcome rate secondary pregnancy Simple multivariate logistic regression analyses performed. Main results role chance median 42 years (interquartile range [IQR] 19–50) (IQR 19–76), respectively. mean donors 26 18-35). 55.5% [N = 182] corresponded 44.5% 146] frozen transfers. Indications using reserve 54.39%, insufficiency 5.7%, 37.05% 2.85%. overall 155/328 (45.7%). Live appeared be significantly reduced over 46 after adjusting semen parameters WHO 2010 OR 1.5 (95%,0.85 1.98, p < 0.002). Clinical 51 0.62 (95%, 0.31 1.89, 0.0001). 15/328 (4.57%) it perform subgroup analysis by group due small numbers. When both retained model, probability decreased ≥40 0.88 [0.40 1.38 37]). Limitations, reasons caution has some limitations. its relatively sizes affected statistical In addition, we include any DNA fragmentation analysis. Wider implications findings positive. Whilst can counsel should preclude patients from treatment. Trial registration number IRB-003C02-09-21